ABC and ESPN 2022 MLS Television Schedule:
| Date | Time (ET) | Match | Networks |
| Sun, Feb 27 | 5 p.m. | LA Galaxy vs. New York City FC | ESPN, ESPN Deportes |
| Sun, Mar 6 | 4 p.m. | Austin FC vs. Inter Miami CF | ESPN, ESPN Deportes |
| Sun, Mar 27 | 4 p.m. | Portland Timbers vs. Orlando City SC | ESPN, ESPN Deportes |
| Sat, Apr 9 | 3 p.m. | Inter Miami CF vs. New England Revolution | ESPN, ESPN Deportes |
| Sun, Apr 10 | 1:30 p.m. | Charlotte FC vs. Atlanta United | ABC, ESPN Deportes |
| Sun, Apr 17 | 4 p.m. | Los Angeles FC vs. Sporting Kansas City | ESPN, ESPN Deportes |
| Sat, Apr 23 | 5 p.m. | Minnesota United vs. Chicago Fire | ESPN, ESPN Deportes |
| Sun, Apr 24 | 1 p.m. | Inter Miami CF vs. Atlanta United | ESPN, ESPN Deportes |
| 3:30 p.m. | Orlando City SC vs. New York Red Bulls | ESPN, ESPN Deportes | |
| Sun, May 1 | 4 p.m. | Nashville SC vs. Philadelphia Union | ESPN, ESPN Deportes |
| Sun, May 15 | 2 p.m. | Atlanta United vs. New England Revolution | ESPN, ESPN Deportes |
| 4 p.m. | Seattle Sounders vs. Minnesota United | ESPN, ESPN Deportes | |
| Sat, Jun 11 | 3 p.m. | Charlotte FC vs. New York Red Bulls | ABC, ESPN Deportes |
| Sun, Jun 12 | 3 p.m. | Sporting Kansas City vs. New England Revolution | ABC, ESPN Deportes |
| Sat, Jun 18 | 3 p.m. | Seattle Sounders vs. Los Angeles FC | ABC, ESPN Deportes |
| 5 p.m. | LA Galaxy vs. Portland Timbers | ESPN, ESPN Deportes | |
| Sun, Jun 19 | 4 p.m. | Atlanta United vs. Inter Miami CF | ESPN2, ESPN Deportes |
| Sat, Jun 25 | 3 p.m. | Seattle Sounders vs. Sporting Kansas City | ABC, ESPN Deportes |
| 5 p.m. | DC United vs. Nashville SC | ESPN, ESPN Deportes | |
| Sun, Jun 26 | 3 p.m. | Los Angeles FC vs. New York Red Bulls | ABC, ESPN Deportes |
| Fri, Jul 8 | 8:30 p.m. | Philadelphia Union vs. DC United | ESPN, ESPN Deportes |
| 10 p.m. | Los Angeles FC vs. Los Angeles Galaxy | ESPN, ESPN Deportes | |
| Wed, Jul 13 | 8 p.m. | Minnesota United vs. Sporting Kansas City | ESPN, ESPN Deportes |
| Sun, Jul 17 | 3 p.m. | Atlanta United vs. Orlando City SC | ABC, ESPN Deportes |
| 5 p.m. | New York Red Bulls vs. New York City FC | ESPN, ESPN Deportes | |
| Sat, Jul 30 | 3 p.m. | Minnesota United vs. Portland Timbers | ABC, ESPN Deportes |
| Sat, Aug 6 | 3 p.m. | Atlanta United vs. Seattle Sounders | ABC, ESPN Deportes |
| Wed, Aug 10 | 8 p.m. | MLS All-Star Game (TBD) | ESPN |
| Fri, Aug 19 | 10 p.m. | LA Galaxy vs. Seattle Sounders | ESPN, ESPN Deportes |
| Fri, Aug 26 | 8 p.m. | Austin FC vs. Los Angeles FC | ESPN, ESPN Deportes |
| 10 p.m. | Portland Timbers vs. Seattle Sounders | ESPN, ESPN Deportes | |
| Sun, Sep 11 | 1 p.m. | TBD | ESPN, ESPN Deportes |
| Sun, Sep 18 | 1 p.m. | Columbus Crew vs. Portland Timbers | ESPN, ESPN Deportes |
| Sun, Oct 2 | 3 p.m. | Portland Timbers vs. Los Angeles FC | ABC, ESPN Deportes |
| Sun, Oct 9 | 5 p.m. | Decision Day | ESPN, ESPN Deportes |
* Schedule Subject to Change
* All matches will stream live on the ESPN App